from the Department of Oncology, Cambridge
Talk time: Wednesday 19th March, 6-7pm. Arrive at 5:30pm for a chance to chat with the speakers prior to the talk. You will not get a chance during the formal as they will be sat at the high table!
Location: Tim Cadbury/Music Room, staircase E
Dr Daniel Munoz-Espin will discuss “Role of Cellular Senescence in Ageing and Cancer: Therapeutic Opportunities”.
Summary: Cellular senescence is a response to unrepairable damage and stress, and it is characterised by the implementation of a stable cell cycle arrest and potent proinflammatory phenotype (SASP). We will recapitulate physiological roles of senescence playing an active contribution in embryonic development, wound healing and tumour suppression. However, when senescent cells are not cleared by the immune system their physiological roles deregulate and turn into pathological manifestations that result in tissue dysfunction, chronic inflammation, a number of age-related disorders and the acceleration of ageing. We will discuss crucial therapeutic strategies to manipulate senescence in disease.
Dr Jianfeng Ge will discuss “CRISPR Screening for the Identification of Senolytic Targets in Ageing and Cancer”
Summary: “Preclinical models have shown that eliminating senescent cells using Senotherapies can reverse age-related disorders and extend lifespan in mice. However, the heterogeneity of senescence and the lack of specific biomarkers hinder the clinical translation of Senolytic drugs. Developing more precise biomarkers and next-generation Senolytic compounds is crucial for overcoming these challenges.”